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  • PanEcho

    Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning

    JAMA

  • 1-lead HF Pred

    Using Artificial Intelligence to Predict Heart Failure Risk from Single-lead Electrocardiographic Signals: A Multinational Assessment

    JAMA Cardiology

  • Tirzepatide in T2DM

    Effects of Tirzepatide in Type 2 Diabetes: Individual Variation and Relationship to Cardiometabolic Outcomes

    JACC

  • ELSA-Brasil Study

    Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study

    Open Heart

  • PRESENT SHD

    Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD

    JACC

  • AI POCUS

    Artificial intelligence-guided detection of under-recognised cardiomyopathies on point-of-care cardiac ultrasonography: a multicentre study

    The Lancet Digital Health

  • NLP Functional Status

    Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure

    JAMA Network Open

  • Echo-based AS Detection

    Severe aortic stenosis detection by deep learning applied to echocardiography

    European Heart Journal

  • HF Risk Stratification

    Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study

    European Heart Journal

  • Digital Twin Technology

    Cardiovascular care with digital twin technology in the era of generative artificial intelligence

    European Heart Journal

  • ARISE for LPA Screening

    Development and multinational validation of an algorithmic strategy for high Lp(a) screening

    Nature Cardiovascular Research

Publications

Electrocardiogram-Based Deep Learning to Prioritize Testing for Transthyretin Amyloid Cardiomyopathy

Philip M. Croon, Bruno Batinica, Lovedeep S. Dhingra, Ryan B. Choi, Evangelos K. Oikonomou, Sumukh V. Shankar, Veer Sangha, Robert M. A. van der Boon, Michelle Michels, Maarten van Ettinger, Peter-Paul Zwetsloot, Sergio Teruya, Cesia Gallegos Kattan, Edward J. Miller, Navid Noory, Oscar M. Westin, Sie K. Fensman, Steen Hvitfeldt Poulsen, Avneet Singh, Sudarshan Balla, Anouk Achten, Charalambos Vlachopoulos, Alexios S. Antonopoulos, Nico Bruining, Julian D. Gillmore, Mathew S. Maurer, Frederick L. Ruberg, Marianna Fontana, and Rohan Khera

JAMA. August 2026

AI-Enabled Echocardiography Identifies an Adverse Epicardial Adiposity Phenotype Associated with Cardiometabolic Dysfunction

Arya Aminorroaya, Andreas Coppi, Robert L. McNamara, Joao A. C. Lima, Harlan M. Krumholz, Charalambos Antoniades, Rohan Khera, and Evangelos K. Oikonomou

medRxiv. July 2026

Digital phenotyping of aortic stenosis-related remodeling reveals complementary structural, electrical, and hemodynamic signatures

Wenjing Luo, Ryan B. Choi, Doris Yang, Lovedeep S. Dhingra, Philip M. Croon, Rohan Khera, and Evangelos K. Oikonomou

medRxiv. July 2026

Autonomous Agents for Auditable Cardiovascular Artificial Intelligence Development

Lovedeep S. Dhingra, Bruno Batinica, Ryan B. Choi, Philip M. Croon, Evangelos K. Oikonomou, and Rohan Khera

medRxiv. July 2026

From Detection to Differentiation: The Evolving Role of Artificial Intelligence-Enabled ECG in Heart Failure Care

Bruno Batinica, Aline F. Pedroso, and Rohan Khera

Journal of the American Heart Association. July 2026

Multimodal Deep Learning Reveals the Modular Genetic Architecture of Cardiovascular Aging

Ryan B. Choi, Philip M. Croon, Sudheesha Perera, Lovedeep S. Dhingra, Bruno Batinica, Evangelos K. Oikonomou, and Rohan Khera

medRxiv. July 2026

Artificial intelligence and the evolution of the electrocardiogram: from cardiovascular diagnostic tool to digital biomarker

Ryan B. Choi and Rohan Khera

European Heart Journal Digital Health. June 2026

Use of Social Media for Health Information Among US Adults

Aline F. Pedroso, Lovedeep S. Dhingra, Mariam Khan, Madeleine Carter, Arya Aminorroaya, and Rohan Khera

JAMA. June 2026

Artificial intelligence-enabled electrocardiography to triage echocardiography for structural heart disease diagnosis in a low-resource setting

Aline F. Pedroso, Bruno R. Nascimento, Lovedeep S. Dhingra, Sumukh V. Shankar, Wanessa C. Vinhal, Raldner B. E. Reges, Clareci S. Cardoso, Craig Sable, Antonio L. P. Ribeiro, and Rohan Khera

American Journal of Preventive Cardiology. June 2026

Wearable Devices and Data Sharing in the US

Aline F. Pedroso, Lovedeep S. Dhingra, Arya Aminorroaya, and Rohan Khera

JAMA Network Open. June 2026

Response by Croon and Khera to Letter Regarding Article, "Phenotypic Selectivity of Artificial Intelligence-Enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction"

Philip M. Croon and Rohan Khera

Circulation. May 2026

The Evolving Utility of Artificial Intelligence-Based Tools for the Detection of Heart Failure and Cardiomyopathies: From Potential to Implementation

Philip M. Croon, Lovedeep S. Dhingra, Aline F. Pedroso, and Rohan Khera

Current Heart Failure Reports. May 2026

Wearable-Echo-FM: an ECG echo foundation model for 1-lead electrocardiography

Elizabeth Knight, Evangelos K. Oikonomou, Arya Aminorroaya, Aline F. Pedroso, and Rohan Khera

European Heart Journal - Digital Health. May 2026

Open science requires trust and rigour: a framework for responsible evaluation of shared AI-ECG tools

Lovedeep S. Dhingra, Philip M. Croon, Evangelos K. Oikonomou, and Rohan Khera

European Heart Journal - Digital Health. May 2026

Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Diabetes Mellitus

Fan Bu, Ruopeng Wu, Anna Ostropolets, Arya Aminorroaya, Hsin Yi Chen, Yi Chai, Lovedeep S. Dhingra, Thomas Falconer, Jason C. Hsu, Chungsoo Kim, Wallis C. Y. Lau, Kenneth K. C. Man, Evan Minty, Daniel R. Morales, Akihiko Nishimura, Phyllis Thangraraj, Mui Van Zandt, Can Yin, Rohan Khera, George Hripcsak, and Marc A. Suchard

JACC. April 2026

Early Prediction of Heart Failure From Routine Cardiac CT Using Radiomic Phenotyping of Epicardial Fat

Evangelos K. Oikonomou, Kenneth Chan, Parijat Patel, Elizabeth Wahome, Katerina Dangas, Rohan Desai, Ikboljon Sobirov, Rohan Khera, Steffen E. Petersen, Francesca Pugliese, Ronak Rajani, Edward Nicol, Attila Kardos, David Adlam, Andrew D. Kelion, Nikant Sabharwal, Nicholas Screaton, John P. Greenwood, Jonathan Rodrigues, Daniel Huck, Cheerag Shirodaria, Pete Tomlins, Muhammad Siddique, Yogesh Sohan, Sam Fry, Marly van Assen, Ron Blankstein, Milind Y. Desai, Stefan Neubauer, Keith M. Channon, John Deanfield, Charalambos Antoniades; ORFAN Consortium

JACC. April 2026

Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes

Chungsoo Kim, Fan Bu, Clair Blacketer, Anna Ostropolets, Talita Duarte-Salles, Benjamin Viernes, Thomas Falconer, Andrea Pistillo, Jing Li, Can Yin, Mui Van Zandt, Paul Nagy, Akihiko Nishimura, Evan Minty, Seng Chan You, Mitsuaki Sawano, Shoko Sawano, Ja Young Jeon, Arya Aminorroaya, Lovedeep S. Dhingra, Aline F. Pedroso, Phyllis Thangaraj, David A. Dorr, Nicole Pratt, Kenneth K. C. Man, Wallis C. Y. Lau, Daniel R. Morales, Rohan Khera, Martijn J. Schuemie, Patrick B. Ryan, George Hripcsak, Harlan M. Krumholz, Marc A. Suchard, and Yuan Lu

Nature Communications. April 2026

Response by Oikonomou et al to Letter Regarding Article, "Artificial Intelligence-Enabled Echocardiography as a Surrogate for Multimodality Aortic Stenosis Imaging: Post Hoc Analysis of a Clinical Trial"

Evangelos K. Oikonomou, Marc R. Dweck, and Rohan Khera

Circulation: Cardiovascular Imaging. March 2026

Artificial Intelligence-enhanced Electrocardiography for Heart Failure Screening and Risk Stratification

Lovedeep S. Dhingra, Philip M. Croon, Bruno Batinica, Arya Aminorroaya, Aline F. Pedroso, and Rohan Khera

Current Heart Failure Reports. March 2026

A novel digital twin strategy to examine the implications of randomized clinical trials for real-world populations

Phyllis M. Thangaraj, Sumukh V. Shankar, Sicong Huang, Girish N. Nadkarni, Bobak J. Mortazavi, Evangelos K. Oikonomou, and Rohan Khera

npj Digital Medicine. March 2026

A real-world evaluation of longitudinal healthcare expenses in a health system registry of type-2 diabetes mellitus and cardiovascular disease enabled by the 21st century cures act

Lovedeep S. Dhingra, Aline F. Pedroso, Arya Aminorroaya, Jigar Rajpura, Sherif Mehanna, Ivy Tonnu-Mihara, and Rohan Khera

American Journal of Preventive Cardiology. February 2026

Cardiovascular risk stratification without recalibration: A comparative study of the PREVENT and WHO risk scores in a multiethnic Brazilian cohort

Aline F. Pedroso, Luisa C. C. Brant, Antonio L. P. Ribeiro, Sandhi M. Barreto, Roberta C. Figueiredo, and Rohan Khera

American Journal of Preventive Cardiology. February 2026

Artificial intelligence-based automated interpretation of images of electrocardiograms: development and multinational validation of ECG-GPT

Akshay Khunte, Veer Sangha, Evangelos K. Oikonomou, Lovedeep S. Dhingra, Arya Aminorroaya, Andreas Coppi, Sumukh V. Shankar, Elijah Rockers, Bobak J. Mortazavi, Deepak L. Bhatt, Harlan M. Krumholz, Sadeer Al-Kindi, Girish N. Nadkarni, Akhil Vaid, and Rohan Khera

European Heart Journal - Digital Health. February 2026

Machine learning to predict elevated lipoprotein(a)

Arya Aminorroaya and Rohan Khera

Current Opinion in Lipidology. January 2026

Development and Multinational Validation of Artificial Intelligence-Enabled ASCVD Risk Stratification Using Electrocardiograms

Bruno Batinica, Evangelos K. Oikonomou, Aline F. Pedroso, Arya Aminorroaya, Dhruva Biswas, Lovedeep S. Dhingra, and Rohan Khera

medRxiv. January 2026

Follow-Up Assessment of Adherence to Methodological Standards in National Inpatient Sample Research

Lovedeep S. Dhingra, Aline F. Pedroso, Arya Aminorroaya, César Caraballo, Shiwani Mahajan, Bhavik Bansal, Harlan M. Krumholz, and Rohan Khera

JAMA Network Open. January 2026

Artificial Intelligence–Enhanced Electrocardiogram Models for Detection of Left Ventricular Dysfunction: A Comparison Study

Philip M. Croon, Machteld J. Boonstra, Cornelis P. Allaart, Bauke K. O. Arends, Lovedeep S. Dhingra, Yu-Chang Huang, Thomas Mast, Rohan Khera, Chang-Fu Kuo, Joon-Myoung Kwon, Hak Seung Lee, Min Sung Lee, Rutger R. van de Leur, Zhi-Yong Liu, Evangelos K. Oikonomou, Jasper L. Selder, Michiel M. Winter, and Folkert W. Asselbergs

JACC: Advances. January 2026

Artificial Intelligence-Enabled Echocardiography as a Surrogate for Multimodality Aortic Stenosis Imaging: Post Hoc Analysis of a Clinical Trial

Evangelos K. Oikonomou, Neil J. Craig, Gregory Holste, Sumukh Vasisht Shankar, Audrey White, Menaka Mahendran, David E. Newby, Marc R. Dweck, and Rohan Khera

Circulation: Cardiovascular Imaging. December 2025

Evaluating the Accessibility of Transcatheter and Surgical Aortic Valve Replacement Across the US Via Driving-Times

Sohum Kapadia, Miles Shen, Jonathan Hanna, Kevin Wheelock, Aline F. Pedroso, Amit Vora, Lovedeep S. Dhingra, Arya Aminorroaya, and Rohan Khera

The American Journal of Cardiology. December 2025

Artificial Intelligence for Cardiovascular Care in Action: From Learning to Implementation in Health Systems

Dhruva Biswas, Phyllis Thangaraj, Aline F. Pedroso, Modele O. Ogunniyi, Thomas M. Maddox, Faraz S. Ahmad, and Rohan Khera

JACC: Advances. December 2025

Distributed Precision Stroke Care: Artificial Intelligence-Driven Stroke Management Using Multimodal Sensor Data

Aline F. Pedroso, Lee H. Schwamm, and Rohan Khera

Stroke. October 2025

Scientific Writing in the Era of Large Language Models: A Computational Analysis of AI- Versus Human-Created Content

Rohan Khera, Aline F. Pedroso, Vipina K. Keloth, Hua Xu, Gisele S. Silva, and Lee H. Schwamm

Stroke. October 2025

Phenotypic Selectivity of Artificial Intelligence-enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction

Philip M. Croon, Lovedeep S. Dhingra, Dhruva Biswas, Evangelos K. Oikonomou, and Rohan Khera

Circulation. September 2025

Transforming Population Health Screening for Atherosclerotic Cardiovascular Disease with AI-Enhanced ECG Analytics: Opportunities and Challenges

Dhruva Biswas, Arya Aminorroaya, Philip M. Croon, Bruno Batinica, Aline F. Pedroso, and Rohan Khera

Current Atherosclerosis Reports. September 2025

Access to electrophysiologic care for Medicare beneficiaries across the United States: Travel distance and time to nearest clinician, 2013–2020

Pegah Khaloo, Kevin M. Wheelock, Jonathan Hanna, Sohum Kapadia, Aline F. Pedroso, Wafa Nabi, Arya Aminorroaya, James V. Freeman, and Rohan Khera

Heart Rhythm. September 2025

National Patterns of Remote Patient Monitoring Service Availability at US Hospitals

Aline F. Pedroso, Zhenqiu Lin, Joseph S. Ross, and Rohan Khera

Circulation: Cardiovascular Quality and Outcomes. August 2025

Identification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning

Veer Sangha, Lovedeep S. Dhingra, Arya Aminorroaya, Philip M. Croon, Nikhil V. Sikand, Sounok Sen, Matthew W. Martinez, Martin S. Maron, Harlan M. Krumholz, Folkert W. Asselbergs, Evangelos K. Oikonomou, and Rohan Khera

Nature Cardiovascular Research. July 2025

Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy

Evangelos K. Oikonomou, Veer Sangha, Sumukh V. Shankar, Andreas Coppi, Harlan M. Krumholz, Khurram Nasir, Edward J .Miller, Cesia Gallegos Kattan, Mouaz H. Al-Mallah, Sadeer Al-Kindi, and Rohan Khera

European Heart Journal. July 2025

Leveraging AI-enhanced digital health with consumer devices for scalable cardiovascular screening, prediction, and monitoring

Aline F. Pedroso and Rohan Khera

NPJ Cardiovascular Health. July 2025

Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning

Gregory Holste, Evangelos K. Oikonomou, Márton Tokodi, Attila Kovács, Zhangyang Wang, and Rohan Khera

JAMA. June 2025

A Novel Sentence Transformer-based Natural Language Processing Approach for Schema Mapping of Electronic Health Records to the OMOP Common Data Model

Xinyu Zhou, Lovedeep S. Dhingra, Arya Aminorroaya, Philip Adejumo, and Rohan Khera

AMIA Annual Symposium Proceedings Archive. May 2025

Effects of Tirzepatide in Type 2 Diabetes: Individual Variation and Relationship to Cardiometabolic Outcomes

Arya Aminorroaya, Evangelos K. Oikonomou, Dhruva Biswas. Ania M. Jastreboff, and Rohan Khera

Journal of the American College of Cardiology. May 2025

Computational Phenomapping of Randomized Clinical Trials to Enable Assessment of their Real-world Representativeness and Personalized Inference

Phyllis M. Thangaraj, Evangelos K. Oikonomou, Lovedeep S. Dhingra, Arya Aminorroaya, Rahul Jayaram, Marc A. Suchard, and Rohan Khera

Circulation: Cardiovascular Quality and Outcomes.  April  2025

Artificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms

Lovedeep S. Dhingra, Arya Aminorroaya, Aline F. Pedroso, Akshay Khunte, Veer Sangha, Daniel McIntyre, MD, Clara K. Chow, Folkert W. Asselbergs, MD, Luisa C. C. Brant,Sandhi M. Barreto, MD, Antonio Luiz P. Ribeiro, Harlan M. Krumholz, Evangelos K. Oikonomou, and Rohan Khera

JAMA Cardiology.  April  2025

Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms

Arya Aminorroaya, Lovedeep S. Dhingra, Aline F. Pedroso, Sumukh V. Shankar, Andreas Coppi, Akshay Khunte, Murilo Foppa, Luisa C. C. Brant, Sandhi M. Barreto, Antonio Luiz P. Ribeiro, Harlan M. Krumholz, Evangelos K. Oikonomou, and Rohan Khera

European Heart Journal - Digital Health.  April  2025

Automated Transformation of Unstructured Cardiovascular Diagnostic Reports into Structured Datasets Using Sequentially Deployed Large Language Models

Sumukh V. Shankar, Lovedeep S. Dhingra, Arya Aminorroaya, Philip Adejumo, Girish N. Nadkarni, Hua Xu, Cynthia Brandt, Evangelos K. Oikonomou, Aline F. Pedroso, and Rohan Khera

European Heart Journal - Digital Health.  April  2025

Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD

Lovedeep S. Dhingra, Arya Aminorroaya, Veer Sangha, Aline F. Pedroso, Sumukh V. Shankar, Andreas Coppi, Murilo Foppa, Luisa C.C. Brant, Sandhi M. Barreto, Antonio Luiz P. Ribeiro, Harlan M. Krumholz, Evangelos K. Oikonomou, and Rohan Khera

The Journal of the American College of Cardiology. March  2025

Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care

Arya Aminorroaya, Dhruva Biswas, Aline F. Pedroso, and Rohan Khera

The Journal of the Society for Cardiovascular Angiography & Interventions. March 2025

Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study

Rohan Khera, Mitsuaki Sawano, Frederick Warner, Andreas Coppi, Aline F Pedroso, Erica S Spatz, Huihui Yu, Michael Gottlieb, Sharon Saydah, Kari A. Stephens, Kristin L. Rising, Joann G. Elmore, Mandy J. Hill, Ahamed H. Idris, Juan Carlos C. Montoy, Kelli N. O’Laughlin, Robert A. Weinstein, and Arjun Venkatesh

Journal of the American Medical Informatics Association. February 2025

A Multicenter Evaluation of the Impact of Therapies on Deep Learning-based Electrocardiographic Hypertrophic Cardiomyopathy Markers

Lovedeep S. Dhingra, Veer Sangha, Ayra Aminorroaya, Robyn Bryde, Andrew Gaballa, Adel H., Nandini Mehra, Harlan M. Krumholz, Sounok Sen, Christopher M. Kramer, Matthew W. Martinez, Milind Y. Desai, Evangelos K. Oikonomou, and Rohan Khera

The American Journal of Cardiology. February 2025

Artificial intelligence-guided detection of under-recognised cardiomyopathies on point-of-care cardiac ultrasonography: a multicentre study

Evangelos K. Oikonomou, Akhil Vaid, Gregory Holste, Andreas Coppi, Robert L. McNamara, Cristiana Baloescu, Harlan M. Krumholz, Zhangyang Wang, Donald J. Apakama, Girish N. Nadkarni, and Rohan Khera

The Lancet Digital Health. February 2025

Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems

Arya Aminorroaya, Lovedeep S. Dhingra, Evangelos K .Oikonomou, and Rohan Khera

Circulation: Genomic and Precision Medicine. January 2025